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M9470023.TXT
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1994-07-02
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Document 0023
DOCN M9470023
TI [Bone marrow granulomas]
DT 9409
AU Vijnovich Baron IA; Barazzutti L; Tartas N; Korin J; Sanchez Avalos JC;
Departamento de Patologiay Citologia, Sanatorio Guemes, Buenos; Aires,
Argentina.
SO Sangre (Barc). 1994 Feb;39(1):35-8. Unique Identifier : AIDSLINE
MED/94255831
AB PURPOSE: To evaluate bone marrow granulomatous lesions in order to
establish their etiology. MATERIAL AND METHODS: 2,250 bone marrow
biopsies were studied during the period of March 1983-March 1991.
Granulomas and/or granulomatous lesions were found in 24 of them
(1.06%). A correlation between histological characteristics, special
stains: PAS, Ziehl Neelsen and Grocott and cultures were done.
Immunohistochemistry was done to evaluate B or T cell-lineage in 4
patients. RESULTS: The 24 patients were biopsied because of the clinical
diagnosis of haematological and non-haematological neoplasias,
infections, AIDS, sarcoidosis and fever of unknown origin. Bone marrow
cellularity ranged from 20% to 75% (M: 49.8%). Myeloid cells were
increased in 54% of the cases. The number of granulomas ranged from 1 to
19 (M: 3.9). The epithelioid cells were the predominant component in 66%
of the cases. Of the 7 patients with non-Hodgkin's lymphoma, 4 had
lymphomatous involvement with granulomatous pattern. These cases showed
predominance of lymphoid cells and vessels in addition to epithelioid
cells. CONCLUSION: We consider that in order to establish a relationship
between infection and granuloma, the identification of a microorganism
through a culture is a more reliable test. We couldn't find any
morphological characteristic which allowed an etiologic diagnosis of
bone marrow granulomas. In case of lesions with a great lymphocytic and
vascular proliferation plus the presence of epithelioid cells and
fibrosis, NHL with bone marrow involvement with a granulomatous pattern
should be strongly considered.
DE Acquired Immunodeficiency Syndrome/COMPLICATIONS Adolescence Adult
Aged Aged, 80 and over Argentina/EPIDEMIOLOGY Bone Marrow
Diseases/*EPIDEMIOLOGY/ETIOLOGY/MICROBIOLOGY/ PATHOLOGY/PARASITOLOGY
Bone Marrow Examination Cryptococcosis/EPIDEMIOLOGY/PATHOLOGY English
Abstract Female Fever of Unknown Origin/COMPLICATIONS
Granuloma/*EPIDEMIOLOGY/ETIOLOGY/MICROBIOLOGY/PATHOLOGY/ PARASITOLOGY
Histoplasmosis/EPIDEMIOLOGY/PATHOLOGY Human Ilium Incidence
Lymphoma, Non-Hodgkin's/COMPLICATIONS Male Middle Age
Tuberculoma/EPIDEMIOLOGY/PATHOLOGY JOURNAL ARTICLE REVIEW REVIEW,
MULTICASE
SOURCE: National Library of Medicine. NOTICE: This material may be
protected by Copyright Law (Title 17, U.S.Code).